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January 26, 2026Physiological ReportsOpen Access

Omega‐3 fatty acid supplementation does not attenuate declines in skeletal muscle mitochondrial area in young, healthy females during immobilization

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Authors

MLMegan LoMBMerryl N. BlackCMChris McGlory

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Overview

Investigates how omega-3 supplementation affects mitochondrial content during immobilization in healthy females, indicating no protective effect.

Key Points

  • This research examines the impact of omega-3 fatty acid supplementation on mitochondrial content during periods of muscle immobilization.
  • Performed leg immobilization for 2 weeks followed by 2 weeks of remobilization.
  • Supplemented twenty healthy females with omega-3 fatty acids or control sunflower oil.
  • Conducted electron microscopic analysis of vastus lateralis biopsies to assess mitochondrial content.
  • Subsarcolemmal mitochondrial content decreased significantly during immobilization in the omega-3 group (−66% compared to control at −9%).
  • Both groups maintained lower subsarcolemmal mitochondrial content even after recovery.
  • Intermyofibrillar mitochondrial content did not decline during immobilization but was lower than baseline after recovery.

Cite This Study

Lo et al. (2026) studied this question.

synapsesocial.com/papers/6977032e722626c4468e8420https://doi.org/10.14814/phy2.70736
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