Comparison of Maternal Serum Level of Calcium, Copper, Zinc, and Selenium between Assisted and Spontaneous Pregnancy

Background: Pregnant women should get enough calcium (Ca), copper (Cu), zinc (Zn), and selenium (Se). The point of this study was to establish the levels of these elements in the serum of pregnant women with assisted pregnancy with respect to maternal age and body mass index (BMI) compared with spontaneous pregnancy. Objectives: Determine the levels of serum Ca, Cu, Zn, and Se between assisted and spontaneous pregnancy. Materials and Methods: The case groups consisted of 150 pregnancies in the first trimester, including 50 women with in vitro fertilization (IVF), 50 women with intrauterine insemination (IUI), 50 women with spontaneous pregnant (SP), and 50 apparently healthy nonpregnant women. Minerals were detected by using the conventional wet acid digestion method. Results: The present study showed a significant decrease in serum Ca and Se levels between groups of SP, IVF, and IUI with nonpregnant the mean are 9.02 ± 0.52, 9.018 ± 0.52, 9.014 ± 0.52, and 9.29 ± 0.31; 88.752 ± 4.87, 89.264 ± 4.43, 89.15 ± 5.71; and 91.224 ± 4.46, respectively. The serum Cu and Zn showed a nonsignificant change. A nonsignificant difference was seen between the different pregnant groups with age groups and the BMI, but the serum Se level showed a significant decrease with BMI ( P < 0.05). Conclusion: Statistical analysis showed Se and Ca were at a significant decrease in serum levels in the 1st trimester between pregnant and nonpregnant women. The serum Cu showed a nonsignificant increase in the first trimester of pregnancy. There was no significant difference in these elements between different groups of pregnant women.