A randomized trial shows ketamine infusions do not improve depression symptoms compared to placebo, implying limited efficacy.
Up to eight infusions of ketamine were not more effective than a psychoactive placebo in reducing depressive symptoms in patients receiving inpatient treatment for depression, a randomized trial has found. Patients receiving ketamine also showed no improvement relative to those receiving midazolam on measures of cognition and quality of life. Study results were published online Oct. 22, 2025 in JAMA Psychiatry .
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A 2026 study studied this question.
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