What question did this study set out to answer?

This review aims to explore the diverse roles of tumor-infiltrating lymphocytes (TILs) as prognostic markers and therapeutic targets in cancer.

Decoding the tumor immune landscape: emerging TIL subsets as prognostic biomarkers and therapeutic targets

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Review investigates TIL functions and their impact on immunotherapy outcomes across different cancers, suggesting new biomarkers.

This review aims to explore the diverse roles of tumor-infiltrating lymphocytes (TILs) as prognostic markers and therapeutic targets in cancer.
Review of TIL subsets including CD3+, CD8+, CD4+, Tregs, TRM cells, and γδ T cells.
Analysis of recent advancements in single-cell sequencing and spatial transcriptomics.
Discussion of TIL roles in immune response and treatment outcomes.
TRM cells linked to better survival and tumor management.
Tregs mainly influence the tumor microenvironment negatively.
γδ T cells exhibit strong anti-cancer properties.

Shaik et al. (2026) studied this question.

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