Cross-sectional study examines inflammation and cognition-related biomarkers in substance use disorder, suggesting biological differences by gender and substance type.
IBI and CRP appear to be the most sensitive indicators of systemic inflammation in SUD, particularly in stimulant and alcohol users. Elevation of IBI supports its potential role as a cognition-related biomarker. Findings highlight biological heterogeneity across substances, genders, and comorbidities, and emphasize the need for future prospective studies with neurocognitive testing and structured tobacco documentation.
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Karataş et al. (2026) studied this question.
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