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High‑Resolution Clinical Profiling of Age and Sex Differences in Substance Use Severity, Comorbidity, and Impulsivity in Two Large Treatment Samples

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The study aims to investigate how substance use severity, comorbidity, and impulsivity vary by age and sex in treatment settings.
Analyzed data from 1,764 individuals from St. Joseph's Hospital Hamilton and 1,253 from Homewood Health Centre.
Examined age (17-25 vs. 26+ years) and sex (female vs. male) effects on substance use and psychiatric symptoms using regression analyses.
Employed shoelace plots and comorbidity-to-diagnosis inflation ratios for descriptive profiling.
61-81% of participants had psychiatric comorbidity, especially with cannabis or illicit drug use disorders.
Young adults showed higher drug use, psychiatric symptoms, and impulsivity, but lower motivation to change.
Females exhibited more anxiety, depression, and PTSD symptoms compared to males.

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Randomized trial reveals differences in substance use severity and impulsivity by age and sex, indicating the need for tailored treatment strategies.

Halladay et al. (2026) studied this question.

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Randomized trial reveals differences in substance use severity and impulsivity by age and sex, indicating the need for tailored treatment strategies.