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January 26, 2026PLoS Computational BiologyOpen Access

How do tumor-associated neutrophils regulate the microenvironmental landscape of brain tumors: Delivery of nano-particles through BBB

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Authors

HCHaneol ChoJLJunho LeeSLSean Lawler

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Overview

Investigates how tumor-associated neutrophils affect glioblastoma growth, suggesting new treatment strategies.

Key Points

  • The aim is to understand how tumor-associated neutrophils regulate the brain tumor environment and explore new treatment approaches.
  • Developed a mathematical model of the GBM-TAN interaction in brain tissue.
  • Analyzed the roles of anti-tumorigenic N1 and pro-tumorigenic N2 neutrophils.
  • Applied therapeutic antibodies to normalize the immune environment.
  • Created a combination therapy using surgery and Trojan neutrophils.
  • Model reveals TANs regulate tumor growth and invasion patterns in brain tissues.
  • Normalizing the immune environment showed reduced glioma growth.
  • Combination therapy may lead to better control of glioma infiltration and lower recurrence.

Cite This Study

Cho et al. (2026) studied this question.

synapsesocial.com/papers/69770413722626c4468e91dfhttps://doi.org/10.1371/journal.pcbi.1013906
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