Key result
Serum CK levels strongly correlate with pulmonary function, particularly sitting and supine FVC.
Why the study?
Does serum creatine kinase (CK) level correlate with pulmonary function in patients with Duchenne muscular dystrophy?
Observational (n=185)
No
Does serum creatine kinase (CK) level correlate with pulmonary function in patients with Duchenne muscular dystrophy?
Effect estimate: Pearson correlation coefficients (sitting FVC %: r=0.676; supine FVC %: r=0.687; MIP %: r=0.515; MEP %: r=0.574)
p-value: p=<0.001
Serum creatine kinase levels are strongly correlated with pulmonary function in patients with Duchenne muscular dystrophy, suggesting CK may serve as a reliable screening test and predictor of respiratory function.
Serum CK level is a reliable screening test even in patients with advanced DMD, and is a strong predictor of pulmonary functions.
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Kim et al. (2017) conducted an observational in Duchenne muscular dystrophy (n=185). Serum creatine kinase (CK) level was evaluated on Correlations between serum CK levels and pulmonary functions (sitting FVC, supine FVC, MIP, MEP) (Pearson correlation coefficients (sitting FVC %: r=0.676; supine FVC %: r=0.687; MIP %: r=0.515; MEP %: r=0.574), p=<0.001). Serum CK levels were strongly correlated with pulmonary function measures, particularly sitting and supine FVC percentages (r=0.676 and r=0.687, respectively, p<0.001).
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