Key result
Duchenne muscular dystrophy links to elevated CK-MB levels suggesting a skeletal rather than cardiac origin.
Why the study?
Serum creatine kinase isoenzyme levels in Duchenne muscular dystrophy patients and their relationship to muscle and cardiac involvement were not fully characterized using sensitive enzyme immunoassay methods.
Are serum levels of CK isoenzymes elevated in Duchenne muscular dystrophy and what is their tissue of origin?
Population
50 patients with Duchenne muscular dystrophy and 39 controls
Comparison
DMD patients vs controls for serum CK isoenzyme levels
Design
Case-control study using sensitive enzyme immunoassay methods
Authors
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MB elevation should not signal cardiac disease in DMD; leaves open skeletal origin pending prospective validation.
Case-Control (n=89)
Are serum levels of CK isoenzymes elevated in Duchenne muscular dystrophy and what is their tissue of origin?
Elevated serum MB in Duchenne muscular dystrophy likely originates from skeletal rather than cardiac muscle, given its poor correlation with ECG findings and good correlation with CA-III.
Mokuno et al. (1987) conducted a case-control in Duchenne muscular dystrophy (n=89). Duchenne muscular dystrophy vs. Controls was evaluated on Serum levels of creatine kinase (CK) isoenzymes (MM, MB, and BB). Duchenne muscular dystrophy patients had higher serum CK isoenzyme levels than controls, with MB levels correlating with CA-III rather than ECG findings, suggesting a skeletal muscle origin.
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