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March 28, 2020New England Journal of Medicine1,345 citationsOpen Access

Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction

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PAPaul W. ArmstrongBPBurkert PieskeKAKevin J. Anstrom

Key Result

Vericiguat reduced the incidence of cardiovascular death or heart failure hospitalization among high-risk patients compared to placebo.

Structured PICO

Does vericiguat reduce the incidence of death from cardiovascular causes or hospitalization for heart failure in patients with high-risk heart failure and reduced ejection fraction?

P
Population
Patients with high-risk heart failure and reduced ejection fraction
I
Intervention
Vericiguat
C
Comparator
Placebo
O
Outcome
Composite of death from cardiovascular causes or hospitalization for heart failurecomposite

Vericiguat reduces the composite of cardiovascular death or heart failure hospitalization in patients with high-risk heart failure and reduced ejection fraction compared to placebo.

Abstract

Among patients with high-risk heart failure, the incidence of death from cardiovascular causes or hospitalization for heart failure was lower among those who received vericiguat than among those who received placebo. (Funded by Merck Sharp VICTORIA ClinicalTrials.gov number, NCT02861534.).

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Cite This Study

Armstrong et al. (2020) studied this question. Vericiguat reduced the incidence of cardiovascular death or heart failure hospitalization among high-risk patients compared to placebo.

synapsesocial.com/papers/697817fb78c42d0bce33a064https://doi.org/10.1056/nejmoa1915928
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