Key result
Cardiomyocytes renew at a rate of 1% annually at age 25, decreasing to 0.45% by age 75, with fewer than 50% replaced over a lifetime.
Population
Humans
Authors
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Supports exploration of regenerative therapies; leaves open confirmation and translation from animal models to human trials.
Adult human cardiomyocytes have the capacity to renew throughout life, providing a biological rationale for developing regenerative therapies for cardiac pathologies.
Bergmann et al. (2009) studied this question. Cardiomyocytes renew at a rate of 1% annually at age 25, decreasing to 0.45% by age 75, with fewer than 50% replaced over a lifetime.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: