Key result
Purified side population stem cells engrafted into cardiac myofibers at a prevalence of approximately 0.02% after myocardial ischemia and reperfusion.
Why the study?
Does transplantation of adult hematopoietic stem cells (SP cells) lead to regeneration of ischemic cardiac muscle and vascular endothelium in mice with myocardial infarction?
Population
Lethally irradiated mice subsequently rendered ischemic by coronary artery occlusion for 60 minutes followed…
Comparison
Transplantation of highly enriched hematopoietic… vs Sham operations
Design
Preclinical
Follow-up
2 or 4 weeks
Authors
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Minimal engraftment cautions against clinical translation; leaves open whether refined stem cell strategies can achieve meaningful cardiac repair.
Cohort (n=22)
No
Does transplantation of adult hematopoietic stem cells (SP cells) lead to regeneration of ischemic cardiac muscle and vascular endothelium in mice with myocardial infarction?
Effect estimate: null (95% CI null)
Absolute Event Rate: 0.02% vs 0%
p-value: p=null
Adult hematopoietic stem cells (SP cells) can migrate into ischemic cardiac tissue and differentiate into cardiomyocytes and endothelial cells, suggesting a potential therapeutic strategy for myocardial infarction.
Jackson et al. (2001) conducted a cohort in myocardial infarction (n=22). purified side population (SP) cells from bone marrow vs. sham operation was evaluated on Engraftment prevalence of SP cells into cardiac myofibers and endothelial cells (null, 95% CI null, p=null). Purified side population stem cells engrafted into cardiac myofibers at a prevalence of approximately 0.02% after myocardial ischemia and reperfusion.
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