This work falls within the framework of applied pharmaceutical chemistry aimed at developing locally accessible therapeutic solutions based on readily available raw materials. It focuses on the synthesis, quality control, and evaluation of the antacid activity of a pharmaceutical-grade magnesium hydroxide (Mg(OH)2) powder, a compound widely used in gastrointestinal therapy for its antacid and dose-dependent laxative properties. The synthesis was carried out by alkaline precipitation from magnesium nitrate and sodium hydroxide solutions, leading to a fine white amorphous powder with very low water solubility and a yield of 99.2%. Qualitative identification tests, including the disodium phosphate reaction, confirmed the presence of magnesium. At the same time, quantitative analyses demonstrated a chemical purity consistent with the requirements of the European Pharmacopoeia, with chloride, sulfate, calcium, and iron contents remaining below the specified limits. Structural confirmation was achieved through complexometric titration and infrared spectroscopy. The assay result (87.48 mg per 0.1 g) further confirmed the conformity of the synthesized product. The antacid activity was investigated using both pH-metric and titrimetric methods, revealing a rapid and effective neutralizing capacity, comparable to that of certain commercial antacids, although slightly lower than that of combined formulations. Overall, these results demonstrate the technical feasibility of producing pharmaceutical-grade magnesium hydroxide locally, offering a reliable and cost-effective alternative for the treatment of gastric hyperacidity and occasional constipation.
MEKAHLIA et al. (Sat,) studied this question.
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