What question did this study set out to answer?

To report a case of tumor lysis syndrome in a patient with nasopharyngeal carcinoma undergoing chemoimmunotherapy.

January 27, 2026Journal of Cancer Research and Practice0 citationsOpen Access

Tumor Lysis Syndrome in a Super-responder to Chemoimmunotherapy for Nasopharyngeal Carcinoma: A Case Report

KCKuan-Yu ChenNational Taiwan University Hospital LLLi-Chun LuNational Taiwan University

Key Points

To report a case of tumor lysis syndrome in a patient with nasopharyngeal carcinoma undergoing chemoimmunotherapy.
Presented case of a 54-year-old male with nasopharyngeal cancer and liver metastasis.
Monitored Epstein–Barr virus viral load and conducted hydration strategies during treatment.
Assessed laboratory results closely after each chemoimmunotherapy cycle.
Patient developed tumor lysis syndrome and acute kidney injury after the first treatment cycle.
Despite an excellent tumor response, the patient required dialysis for 8 months.

Abstract

Abstract We present the case of a 54-year-old male with nasopharyngeal cancer accompanied by huge liver metastasis, an extremely high Epstein–Barr virus viral load, and B symptoms. Despite aggressive hydration and close laboratory monitoring, he developed tumor lysis syndrome (TLS) and acute kidney injury after the first cycle of chemoimmunotherapy. Although the tumor exhibited an excellent response, the patient became dialysis dependent for 8 months. This case highlights the risk of TLS in patients with nasopharyngeal carcinoma with high tumor burden, a rare but easily overlooked complication.

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