The year in cardiology: Imaging

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Cardiovascular death, heart failure, myocardial infarction (n=6238). Intervention: E/E0sr on speckle tracking echocardiography vs. E/E0. Primary outcome: Cardiovascular death, admission for incident heart failure or myocardial infarction (HR 1.08, 95% CI 1.02–1.13, p=0.003).

Dudley Pennell; V Delgado; Juhani Knuuti; Pàl Maurovich-Horvat; Jeroen Bax

doi:10.5937/siks1904193p

January 1, 2019Srce i krvni sudoviOpen Access

The year in cardiology: Imaging

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Key result

Higher E/E0sr linked to ~8% greater risk of major cardiovascular events.

HR 1.08
95% CI 1.02–1.13
P=0.003
n=6,238

Key Points

To review the most relevant 2019 clinical advances in multimodality cardiac imaging and artificial intelligence applications for evaluating heart disease.
Synthesized findings from major observational cohorts and registries evaluating echocardiography, cardiovascular magnetic resonance, nuclear imaging, and machine learning algorithms.
Evaluated left ventricular filling pressure and mechanical dispersion in cohorts of 1238 and 1138 participants from the Copenhagen City Heart Study.
Assessed the association between physician-reported left ventricular ejection fraction and survival across 403 977 echocardiograms in the USA and 45 531 echocardiograms from New Zealand.
Speckle tracking-derived E/E0sr independently predicted cardiovascular death, heart failure admission, or myocardial infarction (HR 1.08, 95% CI 1.02–1.13 per 10 cm increase; P = 0.003) across 11 years of median follow-up.
Each 10 ms increase in left ventricular mechanical dispersion independently predicted cardiovascular death (HR 1.04, 95% CI 1.01–1.06; P = 0.004).
Analysis of 403 977 echocardiograms revealed a U-shaped relationship between left ventricular ejection fraction and all-cause mortality, with lowest risk at 60–65% ejection fraction over 4 years of median follow-up.

Study Design

Type

Cohort (n=6,238)

Multicenter

Yes

Structured PICO

I

Intervention

Multimodality imaging and artificial intelligence

Main Result

Effect estimate: HR 1.08 (95% CI 1.02–1.13)

p-value: p=0.003

This review highlights the most relevant 2019 studies in cardiac imaging, emphasizing the role of advanced echocardiography, CMR, and artificial intelligence in personalized patient management.

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Implication

May support E/E0sr for risk stratification; leaves open prospective validation before adoption.

Abstract

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Cite This Study

Pennell et al. (2019) conducted a cohort in Cardiovascular death, heart failure, myocardial infarction (n=6,238). E/E0sr on speckle tracking echocardiography vs. E/E0 was evaluated on Cardiovascular death, admission for incident heart failure or myocardial infarction (HR 1.08, 95% CI 1.02–1.13, p=0.003). E/E0sr was independently associated with poor outcomes, indicating usefulness in risk stratification.

synapsesocial.com/papers/697854fdccb046adae5173ae https://doi.org/10.5937/siks1904193p

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The year in cardiology: Imaging

Key Points

Study Design

Structured PICO

Main Result

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

The year in cardiology: Imaging

Key Points

Study Design

Structured PICO

Main Result

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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