Key result
Fibrinolytic therapy safely resolves acute postoperative PE in a single patient.
Case Report (n=1)
Fibrinolytic therapy can be successfully and safely applied in patients with acute massive pulmonary embolism and right heart thrombi even in the early postoperative period after major surgery.
May support fibrinolytic use in select postoperative PE; hypothesis-generating and leaves open need for prospective trials.
Pulmonary embolism (PE) is a disease that can lead to sudden cardiac death and in many patients, PE is the result of deep vein thrombosis (DVT). Surgical interventions are a significant risk factor for VTE and are the most common cause of immediate postoperative death. The paper presents a case report of a diagnosis and treatment algorithm applied in a patient who developed acute, pulmonary thromboembolism in an early, postoperative course. An acute, pulmonary thromboembolism has been diagnosed using modern diagnostic tools, according to the recommendations of the European Association of Cardiologists 2019 for the diagnosis and treatment of patients with pulmonary thromboembolism. In the acute phase in our patient, thrombotic masses in the right heart chambers were verified, fibrinolytic therapy with satisfactory therapeutic effect and no side effects was applied. The prognostic evaluation, which is also important in the further evaluation of the patient, was performed at the same time as the diagnosis of pulmonary thromboembolism and risk stratification based on the most common scoring system - the PESI index.
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Šarić et al. (2020) conducted a case report in Acute postoperative pulmonary thromboembolism (n=1). Alteplase (Actilisa) was evaluated on Clinical stabilization. Fibrinolytic therapy with alteplase successfully stabilized a 61-year-old male patient who developed massive acute pulmonary thromboembolism 23 days after a left leg amputation.
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