November 15, 1996Circulation
Surgery for Aortic Regurgitation in Women
Key result
Women undergoing surgery for aortic regurgitation had worse 10-year survival rates (39±9%) compared to men (72±4%), indicating the need for earlier intervention in women.
Why the study?
Does female sex affect postoperative survival in patients undergoing surgery for isolated aortic regurgitation?
Population
Patients undergoing surgery for isolated aortic regurgitation (51 women and 198 men)
Comparison
Surgery for aortic regurgitation in women vs Surgery for aortic regurgitation in men
Design
Cohort
Follow-up
10 years
Authors
Discussion
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Member takes
Implication
Female sex was associated with worse survival after aortic regurgitation surgery; leaves open whether sex-specific thresholds warrant prospective validation.
Key Points
- This research aims to evaluate surgical outcomes for women undergoing surgery for aortic regurgitation compared to men.
- Compared baseline characteristics and postoperative outcomes of 51 women and 198 men from 1980 to 1989.
- Analyzed operative mortality rates and 10-year survival post-surgery.
- Identified independent predictors of late survival for both genders.
- Women had lower rates of surgery for severe left ventricular enlargement compared to men (11% vs 27%, P =.031).
- 10-year survival was significantly worse for women (39±9%) than men (72±4%, P =.0002).
- Female sex independently predicted worse late survival (adjusted relative risk, 1.80; 95% CI, 1.04 to 3.11).
Structured PICO
Does female sex affect postoperative survival in patients undergoing surgery for isolated aortic regurgitation?
P
Population
Patients undergoing surgery for isolated aortic regurgitation (51 women and 198 men)
I
Intervention
Surgery for aortic regurgitation in women
C
Comparator
Surgery for aortic regurgitation in men
O
Outcome
Postoperative outcomes including operative mortality and 10-year survivalhard clinical
Women undergoing surgery for aortic regurgitation have significantly worse 10-year survival than men, suggesting that unadjusted LV diameter criteria delay necessary surgery in women.
Cite This Study
Klodas et al. (1996) studied this question. Women undergoing surgery for aortic regurgitation had worse 10-year survival rates (39±9%) compared to men (72±4%), indicating the need for earlier intervention in women.