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January 31, 2019The Lancet801 citationsOpen Access

Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials

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JAJane ArmitageCBColin BaigentEBElizabeth H Barnes

Key Points

  • To assess the efficacy and safety of statin therapy in older individuals.
  • Conducted an individual participant data meta-analysis pooling data across 28 randomized controlled trials.
  • Evaluated individual participant outcomes across randomized trials to determine the therapeutic impact of statins in older age groups.
  • Assessed the cardiovascular benefits and potential safety concerns associated with statin treatment in older adults.

Abstract

Australian National Health and Medical Research Council, National Institute for Health Research Oxford Biomedical Research Centre, UK Medical Research Council, and British Heart Foundation.

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Cite This Study

Armitage et al. (2019) studied this question.

synapsesocial.com/papers/697e5bfd931e70dd9c8620b6https://doi.org/10.1016/s0140-6736(18)31942-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Statins for the Primary Prevention of Cardiovascular Disease in the Elderly2015 · 10 citations
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  3. 3Effect of Pravastatin on Cardiovascular Events in Older Patients with Myocardial Infarction and Cholesterol Levels in the Average Range: Results of the Cholesterol and Recurrent Events (CARE) Trial1998 · 433 citations
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