Infant Reflux Trial: study protocol for a multicentre randomized controlled trial on the treatment of gastroesophageal reflux disease in infants

Key Points

• To establish a protocol for a multicentre randomized controlled trial evaluating treatments for gastroesophageal reflux disease in infants.
• Design a multicentre randomized controlled trial
• Recruit infants diagnosed with gastroesophageal reflux disease
• Implement various treatment protocols across centers
• Use standardized assessments and data collection methods
• Anticipated outcomes include efficacy of treatments on reflux symptoms in infants
• Assessment of safety and tolerability of interventions
• Expectation to contribute to guidelines for managing reflux in infants