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To analyze the T cell receptor landscape of tumor-infiltrating lymphocytes in pediatric brain tumors and its implications for antitumor immunity.

February 2, 2026Open Access

The T cell receptor landscape of childhood brain tumors

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To analyze the T cell receptor landscape of tumor-infiltrating lymphocytes in pediatric brain tumors and its implications for antitumor immunity.
Comprehensive examination of TCR repertoire in pediatric brain tumors
Assessment of clonality index and patient prognosis
Clustering analysis of TCR similarity
Identification of tumor antigens through computational analysis
Validation of antigens using T cell stimulation assays
Higher T cell clonality is linked to better patient outcomes
Identified patient clusters with specific human leukocyte antigen associations
Discovered putative tumor antigens as targets for T cell immunity
Established a framework for predicting tumor antigens based on TIL TCR analyses

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Large-scale analysis reveals T cell receptor diversity in childhood brain tumors, suggesting implications for immunotherapy.

Raphael et al. (2025) studied this question.

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