What question did this study set out to answer?

The research aims to develop a one-pot synthesis method for thiocyanato-containing polycyclic indolones.

February 2, 2026The Journal of Organic Chemistry0 citations

One-Pot Synthesis of Thiocyanato-Containing Polycyclic Indolones through Photo-Induced Cascade Radical Cyclization/Thiocyanation/Oxidation of N -Acylindoles

CSChukai ShaoBeijing Institute of Technology LCL. ChenShanghai Liangyou (China)RHRuirui HuaShanghai Liangyou (China)

Key Points

The research aims to develop a one-pot synthesis method for thiocyanato-containing polycyclic indolones.
Used photoinduced radical processes for synthesis
Focused on cascade cyclization/thiocyanation/oxidation
Applied to a variety of N-acylindoles
Conducted under mild and metal-free conditions
Achieved moderate to good yields of products
Identified a range of well-tolerated substrates
Successfully synthesized thiocyanato-containing oxazino and quinazolin compounds

Abstract

A photoinduced radical cascade cyclization/thiocyanation of N-acylindoles has been developed to obtain a series of thiocyanato-containing 1,3oxazino3,4-aindolones and indolo2,1-bquinazolin-12(5H)-ones. A wide scope of substrates has been tolerated in moderate to good yields under mild and metal-free conditions.

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