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The study aims to identify factors associated with difficult-to-treat rheumatoid arthritis (D2T-RA).

Factors Associated with Difficult-to-Treat Rheumatoid Arthritis (D2T-RA): Real-World Evidence from a Single-Center Cross-Sectional Study

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The study aims to identify factors associated with difficult-to-treat rheumatoid arthritis (D2T-RA).
Retrospective evaluation of 344 patients with established rheumatoid arthritis.
Classification into D2T group (164 patients) and NO-D2T group (180 patients) based on EULAR criteria.
Analysis of clinical, laboratory, and therapeutic data including demographics, disease markers, and treatment history.
Female sex, longer disease duration, and higher RF and ACPA titers were significantly associated with D2T-RA.
Glucocorticoid therapy and a greater number of failed advanced therapies were also linked to D2T-RA.
JAK inhibitors, especially Filgotinib and Upadacitinib, were more common in the D2T cohort and associated with clinical stabilization.

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This cross-sectional study identifies factors linked to difficult-to-treat rheumatoid arthritis, highlighting the need for targeted therapies.

Benucci et al. (2026) studied this question.

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This cross-sectional study identifies factors linked to difficult-to-treat rheumatoid arthritis, highlighting the need for targeted therapies.