Observational study examines age-related thickness changes in retinal layers and choriocapillaris in macaques, indicating potential implications for aging research.
Cynomolgus macaques undergo thickening of multiple retinal layers through their juvenile stage. Afterward, macaques undergo thinning of multiple retinal layers with age, suggesting aging-related changes. The increase in choriocapillaris thickness with age in both macaques and humans suggest remodeling due to aging. Cynomolgus macaques represent a valuable NHP model for studying developmental- and aging-related retinal/subretinal changes.
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Han et al. (2026) studied this question.
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