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February 2, 2026Stroke

Abstract DP076: Thrombectomy vs Thrombolysis vs Bridging Therapy in Late-Window Stroke with Salvageable Tissue: A Network Meta-Analysis of Randomized Controlled Trials

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Authors

HHHung Phan HuuMLMinh LeHHHong-Han Huynh

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Overview

Network meta-analysis compares thrombectomy, thrombolysis, and medical therapy in late-window stroke, indicating thrombectomy is superior.

Key Points

  • This research aims to determine the optimal treatment for acute ischemic stroke in late therapeutic windows, focusing on efficacy and safety.
  • Conducted a network meta-analysis of randomized controlled trials (RCTs)
  • Systematically searched databases including MEDLINE and EMBASE
  • Included studies with patients experiencing anterior circulation large vessel occlusion in late window
  • Assessed primary outcome of functional independence and secondary outcomes related to disability and hemorrhage risk
  • Fifteen trials with 4,497 patients included in the analysis
  • EVT reduced 90-day mortality compared to alteplase and tenecteplase
  • EVT associated with better functional outcomes; lower rates of severe disability and intracranial hemorrhage
  • Rankings indicated EVT consistently superior for both efficacy and safety

Cite This Study

Huu et al. (2026) studied this question.

synapsesocial.com/papers/6980fc91c1c9540dea80e677https://doi.org/10.1161/str.57.suppl_1.dp076
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bridging thrombolysis versus direct thrombectomy in acute ischemic stroke with large vessel occlusion: a network meta-analysis2025 · 4 citations
  2. 2Endovascular Thrombectomy Versus Best Medical Therapy for Large Vessel Occlusion Stroke Beyond 24 Hours: A Systematic Review and Meta-Analysis2025 · 10 citations
  3. 3Tenecteplase versus Standard Care for Acute Ischemic Stroke in the 4.5–24 Hour Window: An Updated Systematic Review and Meta-Analysis2026
  4. 4Abstract DP377: Tenecteplase versus Alteplase for Acute Ischemic Stroke Beyond 4.5-Hour Window: A Bayesian Network Meta-Analysis of Randomized Controlled Trials2026
  5. 5Effectiveness and safety of reperfusion strategies within 4.5 hours for large-vessel occlusion stroke: a network meta-analysis2026