Design, synthesis, in vitro , and in silico studies on promising α-glucosidase inhibitors based on a quinazolinone–thiophene scaffold

Parsa Baghershahi; Navid Dastyafteh; Mohammad Halimi; Maryam Mohammadi-Khanaposhtani; Seyedeh Niloufar Ghafouri; Milad Noori; Fahimeh Ghasemi; Somayeh Mojtabavi; Mohammad Ali Faramarzi; Mohammadreza Torabi; Majid Alikhani; Bagher Larijani; Sharzad Javanshir; Mohammad Mahdavi

doi:10.1039/d5ra08206d

January 1, 2026RSC AdvancesOpen Access

Design, synthesis, in vitro , and in silico studies on promising α-glucosidase inhibitors based on a quinazolinone–thiophene scaffold

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Key Points

The central aim is to identify new inhibitors for α-glucosidase through novel scaffold design.
Designed a new scaffold using molecular hybridization techniques.
Conducted in vitro assessments to evaluate inhibitor efficacy.
Used in silico studies for predictive modeling of binding affinity.
Identified novel inhibitors showing promising activity against α-glucosidase.
Demonstrated potential for therapeutic applications in glucose management.

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Implication

Discovers novel α-glucosidase inhibitors using a quinazolinone–thiophene scaffold, suggesting potential therapeutic applications.

Abstract

To discover novel inhibitors for α-glucosidase, a new scaffold featuring a quinazolinone–thiophene skeleton was designed through molecular hybridization.

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Baghershahi et al. (2026) studied this question.

synapsesocial.com/papers/6980fcb6c1c9540dea80e854 https://doi.org/10.1039/d5ra08206d

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Design, synthesis, in vitro , and in silico studies on promising α-glucosidase inhibitors based on a quinazolinone–thiophene scaffold

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Design, synthesis, in vitro , and in silico studies on promising α-glucosidase inhibitors based on a quinazolinone–thiophene scaffold

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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