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This research aims to understand how neural adaptations in the motor cortex affect quadriceps function after ACL reconstruction.

February 2, 2026Brain SciencesOpen Access

Exploratory EEG-TMS Study Reveals Altered Behavioral Function in Individuals Following Anterior Cruciate Ligament Reconstruction

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Exploratory study investigates neural behavior during a motor task in ACLR individuals, indicating neuromuscular changes.

This research aims to understand how neural adaptations in the motor cortex affect quadriceps function after ACL reconstruction.
Compared 16 ACLR participants to 16 healthy controls during an isometric force task.
Measured electrocortical activation using a 64-channel EEG system.
Administered 60 TMS pulses to the primary motor cortex during quadriceps contraction.
Analyzed motor-evoked torque and cortical event-related potentials at three brain regions.
ACLR group showed significantly higher motor-evoked torque than controls.
Lower P200 amplitude at the motor cortex region in ACLR suggests neural inhibition.
Findings suggest increased corticospinal excitability might lead to excessive quadriceps activation.

Huntington et al. (2026) studied this question.

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