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This research focuses on developing a safer method for digesting group IV metal oxides without hydrofluoric acid (HF) to facilitate accurate quantification.

February 2, 2026Open Access

Alternative digestion strategy for Ti, Zr and Hf oxides: eliminating hydrofluoric acid

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This research focuses on developing a safer method for digesting group IV metal oxides without hydrofluoric acid (HF) to facilitate accurate quantification.
Development of a microwave-assisted digestion protocol employing sulfuric acid, water, and hydrogen peroxide mixtures.
Optimization of parameters such as acid-to-peroxide ratios, temperature, and reaction time.
Testing the method on commercially available TiO2, ZrO2, and HfO2 powders.
Validation through quantification of spiked nanoparticles in human cancer cells and bovine liver tissue.
Achieved recoveries exceeding 90% for all tested metal oxides.
Successful quantification with detection limits down to approximately 1 ppb.
Maintained sample stability over four weeks with recoveries within 80-100%.
Provided comparable sensitivity and detection limits to traditional HF-based methods.

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Researchers demonstrate an HF-free method for quantifying metal oxides in biological samples, indicating improved safety and accuracy.

Cite This Study

Gerken et al. (2025) studied this question.

synapsesocial.com/papers/6980fcd6c1c9540dea80e976 https://doi.org/10.5167/uzh-283393

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Alternative digestion strategy for Ti, Zr and Hf oxides: eliminating hydrofluoric acid

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Discussion

Implication

Cite This Study

Alternative digestion strategy for Ti, Zr and Hf oxides: eliminating hydrofluoric acid

Key Points

Discussion

Implication

Cite This Study

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