Palladium-Catalyzed Z-Selective Alkynylation of gem-Difluoro alkenes via Carbon-Fluorine Bond Activation: Mechanistic Insights into Oxygen-Directed Regiocontrol

Key Points

• This research aims to address challenges in synthesizing fluorinated amino acids through a novel reaction pathway.
• Utilized palladium as a catalyst
• Studied carbon-carbon coupling reactions
• Explored carbon-fluorine bond activation mechanisms
• Achieved Z-selective alkynylation of gem-difluoro alkenes
• Identified oxygen-directed regioselectivity
• Demonstrated improved yields in organofluorine compounds