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This review aims to explore the role of RNA processing in both physiological and pathological cardiac hypertrophy.

February 2, 2026The FASEB JournalOpen Access

RNA Processing in Cardiac Hypertrophy: Coordinating Physiological Adaptation and Pathological Remodeling

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This review highlights RNA processing mechanisms affecting cardiac hypertrophy, suggesting new therapeutic approaches for heart disease.

This review aims to explore the role of RNA processing in both physiological and pathological cardiac hypertrophy.
Summarizes current knowledge on RNA modifications and splicing in cardiac hypertrophy.
Examines key proteins and their regulatory functions in RNA processing.
Analyzes the effects of RNA processing on adaptations in exercise-induced and stress-induced hypertrophy.
Identifies key RNA modifications like m6A as crucial for cardiac function.
Demonstrates that RNA processing supports adaptive changes in exercise-induced hypertrophy.
Describes how dysregulated RNA programs contribute to heart failure.

Peng et al. (2026) studied this question.

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