Demonstrates improved bacterial inhibition in silicone catheters using PVA electrospinning membranes, suggesting better infection resistance.
Bacterial adhesion is a primary factor that induces biofilm formation on medical silicone rubber (SR) catheter surface. To endow the SR catheter with antibacterial adhesion behavior, a three-dimensional hydrophilic polyvinyl alcohol (PVA) fiber membrane with different concentrations was constructed on the SR catheter surface using electrospinning technology. Utilizing scanning electron microscopy, contact angle measurements, and bacterial adhesion experiments, the structural and physical characteristics of PVA fiber membrane composite SR catheter (PVA/SR) were explored in detail. The results showed that, with the increase of PVA concentration(6%—10%), the average diameter of the PVA fiber membrane increased from 392.49 ± 24.35 nm to 945.04 ± 12.60 nm, and its uniformity has been enhanced. PVA/SR exhibited excellent hydrophilicity with water contact angles below 95°. In comparison to conventional SR catheter, due to the hydrophilicity and physical barrier of PVA fiber membrane, the PVA/SR catheter demonstrated a notable inhibitory effect on the adhesion of Staphylococcus aureus and Escherichia coli, exhibiting an adhesion inhibition rate of approximately 50%–60%. Furthermore, the PVA/SR catheter exhibits excellent biocompatibility and hemocompatibility. This study provides a novel technology, theoretical basis and experimental foundation for the development of high-performance anti-infective catheter.
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Sun et al. (2026) studied this question.
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