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August 6, 2026ACS OmegaOpen Access

PhotoinitiatedRegulated Silver-Releasing ZwitterionicHydrogel Coating for Antibacterial, Antifouling, and Thrombus-ResistantPVC Catheters

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Authors

QLQinsheng LuUniversity of Shanghai for Science and TechnologyZRZhenyu RenShanghai Chest HospitalQZQianyun ZhangPoultry Research Institute

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Implication

Randomized trial assesses silver-releasing zwitterionic hydrogel coating impact on PVC catheters, indicating strong antibacterial and antifouling properties.

Key Points

  • This research aims to develop a coating for blood-contacting catheters that reduces bacterial colonization and thrombus adhesion.
  • Constructed a photoinitiated silver-loaded zwitterionic hydrogel coating on PVC catheters.
  • Utilized a PDA/BP interfacial layer, pSBMA hydrogel network, and incorporated silver nanoparticles (15.99 ± 0.11 nm).
  • Conducted evaluation of antibacterial efficiency, surface hydrophilicity, and hemocompatibility.
  • Achieved up to 99% antibacterial efficiency against Staphylococcus aureus and Escherichia coli at a silver concentration of 0.05 mM.
  • Reduced thrombus adhesion by approximately 77% compared to bare PVC, with a hemolysis ratio below 2% and cell viability above 80%.
  • Showed reduced inflammatory response and lower expression of IL-6 and CD68 around implanted samples.

Cite This Study

Lu et al. (2026) studied this question.

synapsesocial.com/papers/6a7437ab764cddc9499d52f9https://doi.org/10.1021/acsomega.6c04310
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