Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 2, 2026Stroke

Abstract DP200: Taurine Supplementation Modulates Gut Microbiome and Enhances Stroke Recovery in Aged Mice

View Full Paper
Ask AI
Bookmark
Share

Authors

BCBen CoutureHouston Methodist Sugar Land HospitalNPNaomi PlumaThe University of Texas Health Science Center at HoustonRKRomeesa KhanThe University of Texas Health Science Center at Houston

Discussion

Loading...

Member takes

Implication

Animal study demonstrates taurine promotes recovery after stroke in aged mice, suggesting its potential therapeutic role.

Key Points

  • This research aims to explore how taurine supplementation affects gut microbiome and recovery from stroke in aged mice.
  • Aged mice received transient middle cerebral artery occlusion to induce stroke.
  • Mice were given either taurine supplementation or vehicle treatment post-stroke.
  • Neurologic deficits and behavior were assessed regularly until euthanasia.
  • Flow cytometry analyzed immune changes, and 16S rRNA sequencing assessed gut microbiome composition.
  • Taurine-treated mice lost less weight post-stroke compared to vehicle group (p<0.05).
  • Improvements in neurologic deficit scores were observed in the taurine group (p<0.05).
  • Increased grooming in the sucrose splash test suggested reduced post-stroke depression (p<0.05).
  • Flow cytometry showed reduced cytotoxic T lymphocytes and increased B lymphocytes in taurine-treated mice (**p<0.01).
  • 16S rRNA sequencing indicated an increase in beneficial Enterocloster and a decrease in harmful Bacteroides species (p<0.05).

Cite This Study

Couture et al. (2026) studied this question.

synapsesocial.com/papers/6980fd81c1c9540dea80f455https://doi.org/10.1161/str.57.suppl_1.dp200
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Protection of multiple aspects of Alzheimer’s disease pathology using dietary supplementation with taurine2025
  2. 2Effects of Pre- and Post-Supplementation of Taurine in the Hippocampus of a Gerbil Model of Transient Global Cerebral Ischemia2026 · 1 citations
  3. 3Assessing the protective roles of taurine in Alzheimer's disease mouse models2025
  4. 4Taurine ameliorates sensorimotor function by inhibiting apoptosis and activating A2 astrocytes in mice after subarachnoid hemorrhage2024 · 4 citations
  5. 5Taurine reduces microglia activation in the brain of aged senescence-accelerated mice by increasing the level of TREM22024 · 27 citations