Identifies glucocorticoid receptor signaling's role in immune escape in triple negative breast cancer, suggesting a combined therapy approach.
Our study identifies GR signaling as a tumor-intrinsic immunosuppressive axis in TNBC, transcriptionally activating PD-L1 while repressing MHC-I to drive immune escape. These findings propose GR-targeted therapy combined with immunotherapy as a clinically actionable strategy to reverse immune evasion.
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