What question did this study set out to answer?

To explore the immune characteristics associated with high glucocorticoid receptor (GR) expression in triple-negative breast cancer (TNBC).

Single-Cell Profiling Reveals a Treg-Rich, NK Cell-Depleted Immune Microenvironment in Triple-Negative Breast Cancer with High-Glucocorticoid Receptor Expression

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Analyses reveal a Treg-rich, NK cell-depleted immune microenvironment in GR-high TNBC, suggesting immune suppression.

To explore the immune characteristics associated with high glucocorticoid receptor (GR) expression in triple-negative breast cancer (TNBC).
Utilized imaging mass cytometry (IMC) to profile immune cells in FFPE biopsies from GR-high and GR-low TNBC tumors.
Selected regions of interest within pan-cytokeratin-positive tumor nests for analysis.
Performed unsupervised clustering and identified immune cell types based on protein expression.
GR-high tumors showed significantly higher infiltration of regulatory T cells (Tregs) compared to GR-low tumors.
Higher abundance of activated memory CD8+ T cells, cytotoxic CD4+ T cells, and effector memory CD4+ T cells was observed in GR-high tumors.
GR-low tumors had more HLA-ABC-positive cancer cells and natural killer (NK) cells.
Tregs in GR-high tumors were more frequently located near proliferating tumor cells than those in GR-low tumors.

Behar et al. (2026) studied this question.

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View Full Paper

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Authors

Analyses reveal a Treg-rich, NK cell-depleted immune microenvironment in GR-high TNBC, suggesting immune suppression.

To explore the immune characteristics associated with high glucocorticoid receptor (GR) expression in triple-negative breast cancer (TNBC).
Utilized imaging mass cytometry (IMC) to profile immune cells in FFPE biopsies from GR-high and GR-low TNBC tumors.
Selected regions of interest within pan-cytokeratin-positive tumor nests for analysis.
Performed unsupervised clustering and identified immune cell types based on protein expression.
GR-high tumors showed significantly higher infiltration of regulatory T cells (Tregs) compared to GR-low tumors.
Higher abundance of activated memory CD8+ T cells, cytotoxic CD4+ T cells, and effector memory CD4+ T cells was observed in GR-high tumors.
GR-low tumors had more HLA-ABC-positive cancer cells and natural killer (NK) cells.
Tregs in GR-high tumors were more frequently located near proliferating tumor cells than those in GR-low tumors.

Behar et al. (2026) studied this question.

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