This research demonstrates the role of seipin in obstructing VLDL assembly in hepatocytes, suggesting significant metabolic implications.
These findings suggest that enhanced formation of CLDs driven by seipin may channel lipids storage towards the cytoplasm of hepatocytes, thereby impeding the biogenesis of LLDs and causing defective VLDL lipidation in the ER lumen. Our results thus provide important new insights into the connection between the biogenesis of CLDs and LLDs, as well as VLDL assembly.
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Sun et al. (2026) studied this question.
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