What question did this study set out to answer?

The study aims to evaluate the outcomes of prostate cancer patients treated with radiation therapy, focusing on the significance of high-risk factors, particularly PSA levels.

February 2, 2026Journal of Clinical MedicineOpen Access

High-Risk Prostate Cancer Treated with Radiation Therapy: Favorable Outcomes in Men with PSA > 20 as the Sole High-Risk Factor

View Full Paper

Ask AI

Bookmark

Authors

ASAoi ShimomuraCedars-Sinai Medical Center AKAbed Rahman KawakibiUniversity of Chicago MAMuzamil ArshadUniversity of Chicago Medical Center

Discussion

Member takes

Implication

This analysis demonstrates favorable outcomes in men with prostate cancer treated with radiation therapy, suggesting refined risk stratification.

Key Points

The study aims to evaluate the outcomes of prostate cancer patients treated with radiation therapy, focusing on the significance of high-risk factors, particularly PSA levels.
Analyzed 742 men with prostatic adenocarcinoma treated with curative-intent radiation therapy from 2005 to 2021.
Examined outcomes based on PSA > 20 ng/mL as the sole high-risk feature.
Assessed freedom from biochemical failure and distant metastasis using Kaplan–Meier methods and Cox proportional hazards modeling.
High-risk patients exhibited a 5-year freedom from biochemical failure of 83% and distant metastasis of 89%.
Patients with PSA > 20 ng/mL as their only high-risk feature achieved a 5-year freedom from biochemical failure of 94% compared to 74% for other high-risk patients.
Results indicate that PSA > 20 ng/mL is the weakest NCCN high-risk criterion, suggesting potential for treatment de-escalation.

Cite This Study

Shimomura et al. (2026) studied this question.

synapsesocial.com/papers/6980fde8c1c9540dea80f8bd https://doi.org/10.3390/jcm15031119

View Full Paper

Ask AI

Bookmark

Implication

This analysis demonstrates favorable outcomes in men with prostate cancer treated with radiation therapy, suggesting refined risk stratification.

High-Risk Prostate Cancer Treated with Radiation Therapy: Favorable Outcomes in Men with PSA > 20 as the Sole High-Risk Factor

Discussion

Member takes

Implication

Key Points

Cite This Study

High-Risk Prostate Cancer Treated with Radiation Therapy: Favorable Outcomes in Men with PSA > 20 as the Sole High-Risk Factor

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider