What question did this study set out to answer?

This research aims to compare radiosensitivity and bystander responses in epithelial cells from breast and prostate origins after X-ray exposure.

Radiosensitivity and bystander response in X-ray irradiated tumour and normal epithelial cells of breast and prostate origin

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Compares radiation effects on tumor and normal epithelial cells, suggesting implications for improving radiotherapy.

This research aims to compare radiosensitivity and bystander responses in epithelial cells from breast and prostate origins after X-ray exposure.
Cells were irradiated with X-rays (0, 2, 4 Gy) using a clinical LINAC.
Micronucleus and clonogenic assays quantified DNA damage and survival in the cells.
Multicolour fluorescence in situ hybridization identified chromosomal translocations.
Targeted tumor cells exhibited increased micronucleus frequency and decreased survival fraction compared to control.
Significant differences in radiosensitivity were observed among cell types, with MCF-7 and PC3 being more sensitive.
Both targeted and non-targeted cells showed elevated micronucleus frequency, indicating a bystander effect.

Kabir et al. (2026) studied this question.

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