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January 30, 2026TrialsOpen Access

Hydroxychloroquine sulfate tablets for patients with recurrent implantation failure: a double-blind, randomized, placebo-controlled trial

Dong-Lin Han Lei Li Jing Shi Yimeng Ge Shu-Lin Yang Yifan Chu Zhuo-Yao Mai Y. L. Zhang Hui Chen Yue Jing Gui-Min He Hui-Fen Xiang Jie Zhao Rong Li

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Key Points

To assess the efficacy of hydroxychloroquine sulfate tablets in patients experiencing recurrent implantation failure.
Conducted a double-blind, randomized, placebo-controlled trial.
Enrolled patients with recurrent implantation failure.
Administered hydroxychloroquine sulfate versus a placebo.
The treatment group showed improved outcomes in implantation rates.
Participants reported fewer side effects compared to the placebo group.

Implication

A randomized trial evaluates hydroxychloroquine's effect on implantation failure, suggesting potential benefits.

Discussion

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Cite This Study

Han et al. (2026) studied this question.

synapsesocial.com/papers/6980fe00c1c9540dea80fbd4 https://doi.org/10.1186/s13063-026-09470-4

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Hydroxychloroquine Sulfate Tablets for Patients with Recurrent Implantation Failure: A Double-Blind, randomized, placebo-controlled trial2025
2Hydroxychloroquine treatment for recurrent pregnancy loss: a study protocol for a randomized, double-blind, placebo-controlled trial2024 · 1 citations
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4A three-arm, multicenter, open-label randomized controlled trial of hydroxychloroquine and low-dose prednisone to treat recurrent pregnancy loss in women with undifferentiated connective tissue diseases: Protocol for the immunosuppressant regimens for Living FEtuses (ILIFE) TrialRCT · 2020 · 3 citations
5A three-arm, multicenter, open-label randomized controlled trial of hydroxychloroquine and low-dose prednisone to treat recurrent pregnancy loss in women with undifferentiated connective tissue diseases: Protocol for the immunosuppressant regimens for Living FEtuses (ILIFE) TrialRCT · 2020