Preclinical amyloid pathology is associated with anxiety but not depression in cognitively normal older adults: Evidence for differential neuropsychiatric pathways

Jonathan Vogelgsang; Clara Beck; Regan Patrick; Ipsit V. Vahia; Sara L. Weisenbach

doi:10.1016/j.tjpad.2026.100497

January 30, 2026The Journal of Prevention of Alzheimer s DiseaseOpen Access

Preclinical amyloid pathology is associated with anxiety but not depression in cognitively normal older adults: Evidence for differential neuropsychiatric pathways

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Key Points

To explore how preclinical amyloid pathology relates to anxiety and depression in cognitively normal older adults.
Assess cognitive status of older adults with amyloid pathology.
Evaluate levels of anxiety and depression.
Investigate the relationship between anxiety, depression, and subjective stress.
Findings indicate a direct association between amyloid pathology and anxiety.
Depression shows an indirect association with amyloid pathology through subjective stress.
Distinct neuropsychiatric pathways link anxiety and depression in early Alzheimer's disease.

Implication

Preclinical evidence associates anxiety with amyloid pathology in older adults, suggesting different pathways for anxiety and depression.

Abstract

Preclinical amyloid pathology directly associates with subclinical anxiety but only indirectly with depression through subjective stress, suggesting distinct neuropsychiatric pathways in early AD that could inform detection strategies.

Discussion

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Cite This Study

Vogelgsang et al. (2026) studied this question.

synapsesocial.com/papers/6980fe35c1c9540dea8101d5 https://doi.org/10.1016/j.tjpad.2026.100497

View Full Paper

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Preclinical amyloid pathology is associated with anxiety but not depression in cognitively normal older adults: Evidence for differential neuropsychiatric pathways

Key Points

Implication

Abstract

Discussion

Cite This Study

Preclinical amyloid pathology is associated with anxiety but not depression in cognitively normal older adults: Evidence for differential neuropsychiatric pathways

Key Points

Implication

Abstract

Discussion

Cite This Study

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