This research demonstrates the common epitope recognized by anti-A,B antibodies in blood group O, suggesting a unique molecular structure of antigens.
The serum of people with blood group O contains not only classical anti-A and anti-B, but also anti-A,B antibodies, i.e., those whose Fab region equally recognizes both the A and B blood group antigens. The common epitope of the A and B antigens, recognized by these antibodies, is located strictly on one side of the tetrasaccharide molecule, which was shown by studying their complex with anti-A,B antibodies using the Saturation Transfer Difference (STD NMR) spectroscopy.
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Tsygankova et al. (2025) studied this question.
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