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February 2, 2026Science AdvancesOpen Access

Structural insight into the glucose-6-phosphate transport by G6PT1 and inhibition mechanism of CGA

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Authors

QCQihao ChenPYPu YuanRLRenjie Li

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Overview

Reveals G6PT1's transport mechanism and CGA's inhibitory effect, indicating new therapeutic pathways.

Key Points

  • The aim is to investigate the structural basis of glucose-6-phosphate transport by G6PT1 and how CGA inhibits this process.
  • Determined the structures of G6PT1 in apo state and with G6P, phosphate, and chlorogenic acid.
  • Captured lumen- and cytosol-facing conformations of G6PT1.
  • Analyzed the binding interactions of CGA with G6PT1.
  • Identified G6PT1's mechanism for phosphate-coupled glucose-6-phosphate transport.
  • Showed that CGA stabilizes the transporter in the cytosol-facing state.
  • Demonstrated that CGA competes with substrate binding, inhibiting conformational transitions.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6980fe48c1c9540dea810386https://doi.org/10.1126/sciadv.adz8234
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  5. 5Chlorogenic Acid, a Potential Glucose-6-Phosphatase Inhibitor: An Approach to Develop a Pre-Clinical Glycogen Storage Disease Type I Model2024 · 2 citations