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February 2, 2026AntioxidantsOpen Access

Maternal Exposure to Microplastics and High-Fructose Diet Induces Offspring Hypertension via Disruption of H2S Signaling, Gut Microbiota, and Metabolic Networks

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Authors

CHChien-Ning HsuCHChih-Yao HouYCYu-Wei Chen

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Overview

Experiment shows combined maternal exposure affects hypertension in offspring, suggesting new intervention targets.

Key Points

  • This research investigates how maternal high-fructose diet and microplastics affect offspring hypertension through various mechanisms.
  • Pregnant rats were given a standard chow or a high-fructose diet during pregnancy and lactation.
  • Half of each diet group was additionally exposed to sulfate-modified microplastics.
  • Male offspring were categorized into four groups to assess blood pressure and renal function.
  • Maternal high-fructose or microplastics exposure raised offspring blood pressure, with additive effects from both.
  • Microplastics exposure resulted in renal injury and suppressed H2S-producing enzymes.
  • Alterations in gut microbiota and metabolic pathways related to H2S production were observed.

Cite This Study

Hsu et al. (2026) studied this question.

synapsesocial.com/papers/6980fe57c1c9540dea81047ahttps://doi.org/10.3390/antiox15020179
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