QbD Product Development: Rapid Optimization and Scale-Up of PBAE-Based siRNA Delivery via DoE-Guided Microfluidics

Adrian P.E. Kromer; Laetitia J.M. Eller; David C Jürgens; Olivia M. Merkel

doi:10.1039/d5pm00379b

January 1, 2026RSC PharmaceuticsOpen Access

QbD Product Development: Rapid Optimization and Scale-Up of PBAE-Based siRNA Delivery via DoE-Guided Microfluidics

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Key Points

The study aims to establish design rules for PBAE-based nanoparticles to enhance siRNA delivery efficiency.
Utilized microfluidics for nanoparticle formulation
Employed Design of Experiments (DoE) to assess formulation parameters
Analyzed the relationship between formulation variables and delivery performance
Identified optimal formulation parameters for enhanced siRNA delivery
Demonstrated improved performance of PBAE nanoparticles compared to traditional methods
Highlighted the potential for rapid scale-up of siRNA delivery systems

Implication

This research demonstrates optimized siRNA delivery in nanoparticles, suggesting improved RNA therapies.

Abstract

Poly(β-amino ester) (PBAE)-based nanoparticles have emerged as promising carriers for RNA delivery, yet clear design rules linking formulation parameters to performance are still lacking. In this study, a Quality by...

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Cite This Study

Kromer et al. (2026) studied this question.

synapsesocial.com/papers/6980fe57c1c9540dea810596 https://doi.org/10.1039/d5pm00379b

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QbD Product Development: Rapid Optimization and Scale-Up of PBAE-Based siRNA Delivery via DoE-Guided Microfluidics

Key Points

Implication

Abstract

Discussion

Cite This Study

QbD Product Development: Rapid Optimization and Scale-Up of PBAE-Based siRNA Delivery via DoE-Guided Microfluidics

Key Points

Implication

Abstract

Discussion

Cite This Study

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