Prognostic significance of ventricular stiffness assessed by 3D echocardiography: introducing a novel biventricular stiffness index
Why the study?
Does biventricular stiffness assessed by 3D echocardiography predict death or heart failure hospitalization in patients with non-ischemic dilated cardiomyopathy?
Population
121 consecutive patients with non-ischemic dilated cardiomyopathy (DCM)
Design
Cohort
Follow-up
19±11 months
Key result
A biventricular stiffness index >14 assessed by 3D echocardiography independently predicted death or heart failure hospitalization in patients with non-ischemic DCM (HR 2.59; 95% CI 1.44-4.66; p=0.001).
Authors
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May support BVSI risk stratification in non-ischemic DCM; hypothesis-generating and requires prospective validation before practice change.
Cohort (n=121)
Does biventricular stiffness assessed by 3D echocardiography predict death or heart failure hospitalization in patients with non-ischemic dilated cardiomyopathy?
Biventricular stiffness assessed with 3D echocardiography is an independent predictor of major cardiovascular events in patients with non-ischemic dilated cardiomyopathy.
Hazard Ratio: 2.59 (95% CI 1.44–4.66)
p-value: p=0.001
Vijiiac et al. (2026) conducted a cohort in Non-ischemic dilated cardiomyopathy (DCM) (n=121). Biventricular stiffness index (BVSI) > 14 vs. BVSI ≤ 14 was evaluated on Composite endpoint of death or heart failure decompensation requiring hospitalisation (HR 2.59, 95% CI 1.44-4.66, p=0.001). A biventricular stiffness index >14 assessed by 3D echocardiography independently predicted death or heart failure hospitalization in patients with non-ischemic DCM (HR 2.59; 95% CI 1.44-4.66; p=0.001).