Why the study?
Aortic valve stenosis is linked to higher mortality and clinical events in heart failure, particularly with impaired left ventricular function, but its prevalence and impact required investigation.
Does the presence and severity of aortic stenosis impact all-cause mortality in patients with heart failure?
Observational (n=22,906)
No
Does the presence and severity of aortic stenosis impact all-cause mortality in patients with heart failure?
Moderate or greater untreated aortic stenosis is associated with significantly higher mortality risk across all heart failure subtypes.
Alerts clinicians to heightened mortality risk with untreated AS in HF; extends prognostic data but leaves intervention timing open pending RCTs.
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Heitzinger et al. (2026) conducted an observational in Heart failure (n=22,906). Aortic stenosis vs. Mild or no aortic stenosis was evaluated on All-cause mortality.
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