Key result
Reduced PACS predicts ~7-fold higher AF risk in wtATTR-CM.
Why the study?
Given the high prevalence of AF in patients with wtATTR-CM, early identification of those at elevated risk is essential, and the predictive value of baseline LA strain parameters needed evaluation.
Does baseline left atrial strain analysis predict the development of atrial fibrillation in patients with wild-type transthyretin amyloid cardiomyopathy?
Cohort (n=59)
No
Does baseline left atrial strain analysis predict the development of atrial fibrillation in patients with wild-type transthyretin amyloid cardiomyopathy?
Odds Ratio: 7.368 (95% CI 1.449–37.462)
p-value: p=0.016
In patients with wild-type transthyretin amyloid cardiomyopathy, impaired left atrial strain, particularly reduced Peak Atrial Contraction Strain (PACS), is a strong predictor of incident atrial fibrillation.
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Baseline PACS may aid AF risk stratification in wtATTR-CM; leaves open need for prospective validation before clinical adoption.
Pinheiro et al. (2026) conducted a cohort in Wild-type transthyretin amyloid cardiomyopathy (wtATTR-CM) (n=59). Impaired left atrial strain (PACS and PALS) was evaluated on Incidence of atrial fibrillation during follow-up (OR 7.368, 95% CI 1.449-37.462, p=0.016). A Peak Atrial Contraction Strain cutoff of –11.4% was significantly associated with the development of atrial fibrillation in patients with wtATTR-CM (OR 7.368; 95% CI 1.449–37.462; p=0.016).
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