Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 2, 2026Journal of the Scientific SocietyOpen Access

Evaluation of Anti-inflammatory Effects of Metformin and Dapagliflozin in a Complete Freund’s Adjuvant-induced Arthritis Model in Streptozotocin-induced Diabetic Rats

View Full Paper
Ask AI
Bookmark
Share

Authors

NHNayana HashilkarAHAnil P. HogadeSPSunita Y Patil

Discussion

Loading...

Member takes

Overview

Evaluates anti-inflammatory effects in diabetic rats using metformin and dapagliflozin, indicating potential therapeutic benefits.

Key Points

  • The research aims to assess the effects of diabetes on chronic inflammation and investigate the anti-inflammatory effects of metformin and dapagliflozin in a rat model.
  • Induced diabetes in male Wistar rats using streptozotocin.
  • Modeled chronic inflammation with complete Freund’s adjuvant injection in the right hind paw.
  • Administered metformin, dapagliflozin, or their combination for 28 days.
  • Measured paw edema at defined intervals and analyzed ankle joints histopathologically.
  • Conducted statistical analysis using one-way ANOVA and Tukey’s post hoc test.
  • Diabetic rats showed significantly increased inflammation compared to normal controls.
  • All treatments significantly reduced inflammation levels.
  • Combination therapy compared favorably to monotherapy and aspirin in reducing inflammation.

Cite This Study

Hashilkar et al. (2025) studied this question.

synapsesocial.com/papers/6980feeac1c9540dea811640https://doi.org/10.4103/jss.jss_148_25
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Empagliflozin alone and in combination with metformin mitigates diabetes-associated renal complications2024 · 4 citations
  2. 2933-P: Effects of Dapagliflozin and Metformin on Vascular Function in Newly Diagnosed Type 2 Diabetes—A Randomized Controlled Trial (DMVascular Study)2024
  3. 3Comparative study of cardio-protective effect of metformin versus dapagliflozin in experimentally induced myocardial infarction in diabetic rats2026
  4. 4Combined Metformin and Baricitinib Therapy Attenuates Inflammation in <scp>STZ</scp>‐Induced Diabetic Rats via <scp>AMPK</scp>/<scp>JAK</scp>–<scp>STAT</scp> Pathway Crosstalk2025
  5. 5Effects of ibuprofen in the ZDF rat model of type 2 diabetes2024 · 1 citations