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February 2, 2026Open Access

Fractionally Intensified Chemexfoliation (Ficex): A Novel Concept in Chemical Peels

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Authors

MLMarina LandauHerzliya Medical CenterSLShir Landau-BlumHerzliya Medical CenterFBFotini BageorgouManipal Hospital

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Implication

Demonstrates enhanced skin penetration of peeling agents in cosmetic procedures, suggesting a beneficial combination approach.

Key Points

  • The aim is to introduce the fractionally intensified chemexfoliation (FICEX) technique to improve chemical peel outcomes.
  • Skin specimens harvested from cosmetic surgeries were treated with microneedling only.
  • Alcian blue-stained 30% glycolic acid solution was applied to some specimens.
  • Combination treatment involved applying the glycolic acid solution followed by microneedling.
  • Microneedling created slits in the epidermis using 1.5 mm needles.
  • The glycolic acid solution was confined to the uppermost layers of the epidermis.
  • In combined treatments, columns of glycolic acid were detected in the mid-dermis.

Cite This Study

Landau et al. (2026) studied this question.

synapsesocial.com/papers/6980feeac1c9540dea811693https://doi.org/10.5281/zenodo.18438389
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Also Consider

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  1. 1A novel professional‐use synergistic peel technology to reduce visible hyperpigmentation on face: Clinical evidence and mechanistic understanding by computational biology and optical biopsy2024 · 5 citations
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  3. 3Efficacy of Compound Acid Chemical Peeling in Patients with Moderate Acne: A Prospective Study with Comprehensive Facial Evaluation2026
  4. 4RETRACTED: The Use of Medium‐Deep Peelings to Treat Melasma: A Case Series Study2025 · 1 citations
  5. 5Microneedling Versus Chemical Peels for Atrophic Acne Scars: A Systematic Review and Meta-Analysis2026