What does this research mean for the field?

Compound acid chemical peeling effectively improves moderate acne vulgaris severity while reducing local inflammatory markers and altering the skin microbiome, notably decreasing Staphylococcus abundance. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the clinical efficacy, microbiome alterations, and local inflammatory marker changes following compound acid chemical peeling in patients with moderate acne vulgaris.

August 30, 2026Journal of Visualized Experiments

Efficacy of Compound Acid Chemical Peeling in Patients with Moderate Acne: A Prospective Study with Comprehensive Facial Evaluation

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Authors

MSMengcen Shi RWRuiyao WangThe Affiliated Yongchuan Hospital of Chongqing Medical University GPGanggang PengFirst People's Hospital of Chongqing

Discussion

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Implication

Randomized trial demonstrates improved clinical severity and reduced cutaneous inflammation in moderate acne vulgaris, indicating microbiome and immune modulation.

Key Points

To evaluate the clinical efficacy, microbiome alterations, and local inflammatory marker changes following compound acid chemical peeling in patients with moderate acne vulgaris.
Prospective, split-face, randomized trial enrolling 30 patients with moderate acne vulgaris.
One hemiface received compound acid peeling twice weekly for 3 weeks (6 sessions total) followed by a 9-week observation period, while the contralateral hemiface acted as a delayed-treatment control.
Assessed outcomes using Global Acne Grading System (GAGS) scores, facial imaging, immunohistochemistry for inflammatory markers (IL-1α, IL-6, IL-17, TGF-β, and TLR2), and 16S rRNA gene sequencing.
GAGS scores showed statistically significant improvement following treatment (P < 0.001), alongside reductions in facial redness and porphyrin counts.
Immunohistochemical staining demonstrated decreased expression of IL-1α, IL-6, IL-17, TGF-β, and TLR2, with no adverse events reported.
Skin microbiome alpha diversity decreased, characterized by a significant reduction in the relative abundance of Staphylococcus (P < 0.05).

Cite This Study

Shi et al. (2026) studied this question.

synapsesocial.com/papers/6a93f0f56c1a8fb52e79d8bc https://doi.org/10.3791/72116

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Implication

Randomized trial demonstrates improved clinical severity and reduced cutaneous inflammation in moderate acne vulgaris, indicating microbiome and immune modulation.

Efficacy of Compound Acid Chemical Peeling in Patients with Moderate Acne: A Prospective Study with Comprehensive Facial Evaluation

Discussion

Member takes

Implication

Key Points

Cite This Study

Efficacy of Compound Acid Chemical Peeling in Patients with Moderate Acne: A Prospective Study with Comprehensive Facial Evaluation

Discussion

Member takes

Implication

Key Points

Cite This Study

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