Background Clinical practice guidelines for asthma diagnosis are rarely evaluated in real-life practice. Within the Swiss Paediatric Airway Cohort (SPAC), we initiated the SPAC-asthma project to develop a standardised diagnostic approach for school-aged asthma, based on the algorithm recommended by the European Respiratory Society (ERS) guideline. Here, we report the development and feasibility of this approach after implementation across multiple paediatric pulmonology clinics. Method We used a modified Delphi process with paediatric pulmonologists from participating clinics to tailor the ERS algorithm for feasible implementation in children aged 5–17 years with suspected asthma. Key adaptations included selection of initial tests, criteria for further testing, test cutoffs, the role of medication trial and follow-up procedures. One year after implementation, we evaluated adherence to the adapted approach at four clinics and explored the reasons for any deviations. Results The final SPAC-asthma approach included spirometry, fractional exhaled nitric oxide and allergy testing as initial tests, followed by either bronchodilator reversibility testing, bronchial challenge test or medication trial. Among the 236 children included after one year (median age 9 years), overall adherence to the approach was 77% (182/236, 95% confidence interval: 72–83%). Deviations were due to practice-related ( e.g. , different criteria for bronchial obstruction), patient-related ( e.g. , inability to perform spirometry), and logistical reasons ( e.g. , scheduling difficulties), occurring in 44%, 33% and 22% of the deviations, respectively. Conclusion The diagnostic approach adapted from the ERS guidelines was feasible in most cases, but the observed deviations highlighted the need for flexibility when applying guidelines in real-world settings.
Sasaki et al. (Fri,) studied this question.